| 英文名稱 | Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD Protein |
| 中文名稱 | 重組SARS冠狀病毒2 Spike蛋白RBD 蛋白質(zhì) |
| 別 名 | SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2. |
| 分 子 量 | 51.5kDa |
| 性 狀 | Liquid |
| 種屬同源 | SARS-CoV-2 |
| 多肽活性 | |
| 序 列 | Recombinant SARS-CoV-2 Spike Protein RBD |
| 產(chǎn)品來源 | 基因工程表達(dá) |
| 分 類 | 重組蛋白 |
| 偶聯(lián)蛋白 | |
| 純化方法 | 親和層析 |
| 產(chǎn)品應(yīng)用 | Immunology research |
| 保存條件 | Store at -20 °C for one year. |
| 產(chǎn)品介紹 | The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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