Product Details
- Verified Reactivity
- Human, reacts with Thr2609-phosphorylated DNA-PKcs
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Modified peptide
- Formulation
- This DNA-PKcs antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
ICC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 5.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_315784 (BioLegend Cat. No. 612901) AB_315785 (BioLegend Cat. No. 612902)
Antigen Details
- Structure
- PI3/PI4-Kinases family. Spliced products 460 kD, 470 kD
- Distribution
-
Nuclear
- Function
- Serine/Threonine kinase, dsDNA break repair, VDJ recombination, transcriptional modulator
- Interaction
- Ku70/Ku80, KIP, DNA-ligase IV, XRCC4
- Modification
- Phosphorylation
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, DNA Repair/Replication, Signal Transduction, Transcription Factors
- Molecular Family
- Phospho-Proteins, Protein Kinases/Phosphatase
- Antigen References
-
1. Hartley K, et al. 1995. Cell. 82:849.
2. Connelly M, et al. 1996. Gene. 175:271.
3. Douglas P, et al. 2002. Biochem. J. 368:243
4. Calsou P, et al. 2003. J. Mol. Biol. 326:93. - Regulation
- Must bind DNA ends to become active
- Gene ID
- 5591 View all products for this Gene ID
- UniProt
- View information about DNA-PKcs Phosphorylated on UniProt.org
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