Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TLS/FUS recombinant protein fused with GST tag.
- Formulation
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 0.2 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783440 (BioLegend Cat. No. 855003) AB_2783441 (BioLegend Cat. No. 855004)
Antigen Details
- Structure
- FUS is a 526 amino acid protein with an apparent molecular mass of ~ 53 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Nucleus and cytosol - Function
- FUS/TLS binds to DNA and maintains genomic integrity.
- Interaction
- Interacts with HDAC1, RNA Polymerase II, FUSIP1, ILF3, PRMT1, RELA, SPI1, and TNPO1.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Synaptic Biology
- Molecular Family
- Postsynaptic proteins, Presynaptic proteins
- Antigen References
-
- Efimova AD, et al. 2017. Mol Biol (Mosk) 51:387.
- Ederle H, Dormann D. 2017. FEBS Lett. 591:1489.
- Guerrero EN, et al. 2016. Prog. Neurobiol. 145-146:78.
- Gene ID
- 2521 View all products for this Gene ID 233908 View all products for this Gene ID 217385 View all products for this Gene ID
- UniProt
- View information about FUS on UniProt.org
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