| 產(chǎn)品編號(hào) | bs-42253P |
| 英文名稱 | Recombinant mouse Endothelin-1 protein |
| 中文名稱 | 小鼠內(nèi)皮素1重組蛋白 |
| 別 名 | EDN1_HUMAN; Big endothelin 1; EDN 1; EDN1; EDN1 protein; Endothelin1; Endothelin 1; Endothelin-1; ET 1; ET1; OTTHUMP00000039245; PPET1; Preproendothelin 1; Preproendothelin1. |
| 理論分子量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5mg/ml |
| 物 種 | Mouse |
| 序 列 | 26-202/202 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 標(biāo)簽 | N-His |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 2M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms - ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver. Endothelin 1 is expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Molecular weight: 2491.9 Molecular formula: C109H159N25O32S5 CAS: 117399-94-7 MDL: MFCD00133305 Reconstitution: 1mM (1mg/0.4013mL) SWISS: P22387 Gene ID: 13614 Endothelin-1 (human, porcine)多肽內(nèi)皮素家族的三種異肽之一，是由活化的內(nèi)皮細(xì)胞合成和分泌的，是一種具有強(qiáng)大血管收縮活性的肽，人和豬內(nèi)皮素1序列同源，是有效的內(nèi)源性血管收縮劑。Endothelin-1通過兩種類型受體ETA和ETB發(fā)揮作用。Endothelin-1誘導(dǎo)缺氧誘導(dǎo)因子1α血管內(nèi)皮生長(zhǎng)因子的產(chǎn)生。除了血管收縮作用外，ET-1還會(huì)導(dǎo)致血管細(xì)胞纖維化，刺激活性氧的產(chǎn)生。研究顯示，ET-1誘導(dǎo)促炎機(jī)制，增加超氧陰離子的產(chǎn)生和細(xì)胞因子的分泌。它還可由心肌細(xì)胞釋放。它是活化或功能異常的內(nèi)皮細(xì)胞的一種標(biāo)志物。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.  The purity of the protein is greater than 70% as determined by reducing SDS-PAGE. |
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