產(chǎn)品編號 | bs-43010P |
英文名稱 | Recombinant human MPO protein, C-His (HEK293) |
中文名稱 | 人髓過氧化物酶重組蛋白 |
別 名 | Myeloperoxidase; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN. |
理論分子量 | 82.6kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | >1mg/ml |
物 種 | Human |
純 度 | >90% as determined by SDS-PAGE |
純化方法 | AC |
內(nèi)毒素 | Not analyzed |
表達系統(tǒng) | HEK293 cell |
標簽 | C-His |
緩 沖 液 | PBS (pH=7.4) |
保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
產(chǎn)品介紹 | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] SWISS: P05164 Gene ID: 4353 髓過氧化物酶MPO,作為一種白細胞酶,具有介導炎性反應(yīng)、調(diào)節(jié)免疫應(yīng)答等多種功能,并可參與疾病的發(fā)生發(fā)展過程。同時,髓過氧化物酶基因存在基因多態(tài)性,也影響機體對疾病的易感性. 在正常淋巴組織中和各種髓樣細胞增生癥中,MPO均有較強表達,如:淋巴樣細胞、原核細胞、肥大細胞、漿細胞以及各種上皮源性腫瘤和肉瘤等。 髓過氧化物酶(myeloperoxidase,MPO),是一種血紅素蛋白,富含于中性粒細胞中,由粒細胞進入循環(huán)之前在骨髓內(nèi)合成并存儲于噬天青顆粒內(nèi)。外界刺激可導致中性粒細胞聚集,從而釋放髓過氧化物酶。MPO的相對分子量為150kDa,是由兩個亞單位通過共價結(jié)合形成的四聚體,每個亞單位又有一條重鏈α(相對分子量60kDa)和一條輕鏈β鏈(相對分子量為15kDa)構(gòu)成。(重鏈和輕鏈通過二硫鍵結(jié)合) |
產(chǎn)品圖片 | |
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