產(chǎn)品編號(hào) | bs-43187P |
英文名稱 | Recombinant rabbit CD40L protein (HEK293) |
中文名稱 | 重組兔子CD40L(CD154)蛋白 |
別 名 | TNFSF5; CD 154; CD154; CD 40L; CD154 antigen; CD40 homologue; CD40 ligand; CD40LG; gp39; hCD40L; HIGM1; Hyper IgM syndrome; IGM; IMD3; Ly62; T B cell activating molecule; T cell antigen GP39; TBAM; TNF related activation protein; TNF superfamily member 5; Tnfsf5; TRAP; Tumor necrosis factor (ligand) superfamily member 5; G1SKP7_RABIT. |
性 狀 | Lyophilized or Liquid |
濃 度 | >0.5mg/ml |
物 種 | Rabbit |
純 度 | >90% as determined by SDS-PAGE |
純化方法 | AC |
內(nèi)毒素 | Not analyzed |
表達(dá)系統(tǒng) | HEK293 cell |
緩 沖 液 | PBS (pH=7.4) |
保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
產(chǎn)品介紹 | CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes. SWISS: P27548 Gene ID: 21947 CD40L也是T細(xì)胞活化的重要輔助刺激通路,不僅在調(diào)節(jié)T細(xì)胞免疫反應(yīng)中起關(guān)鍵作用,而且也在B細(xì)胞的活化、增殖、分化、抗體的分泌起重要作用。主要表達(dá)在B細(xì)胞,有抗凋亡和促生長(zhǎng)、分化的作用。 |
產(chǎn)品圖片 | |
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