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重組人色氨酸羥化酶蛋白

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產(chǎn)品編號bs-42199P
英文名稱Recombinant human TPH1 protein, N-His
中文名稱重組人色氨酸羥化酶蛋白
別    名MGC119994; TPH 1; TPH; TPH1; TPRH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan hydroxylase 1; Tryptophan 5-hydroxylase 1; TPH1_HUMAN.  
理論分子量41.2kDa
性    狀Liquid
濃    度>1mg/ml
物    種Human
序    列105-444/444
純    度>90% as determined by SDS-PAGE
純化方法AC
內(nèi)毒素Not analyzed
表達系統(tǒng)E.coli
標簽N-His
緩 沖 液20mM Tris-Hcl (pH=8.0) with 2M Urea
保存條件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].

SWISS:
P17752

Gene ID:
7166

色氨酸在腦中首先由色氨酸羥化酶(tryoptophan hydroxylase)催化生成5羥色氨酸(5hydroxytryptophan),再經(jīng)脫羧酶作用生成5羥色胺,色氨酸羥化酶(TPH)是5-HT生物合成的限速酶,因此,色氨酸羥化酶的缺少可導致5-羥色胺的含量下降。色氨酸羥化酶主要在肝臟內(nèi)代謝。
產(chǎn)品圖片
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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