| 產(chǎn)品編號(hào) | bs-43655P |
| 英文名稱 | Recombinant human Coagulation factor II protein/F2, C-His (HEK293) |
| 中文名稱 | 重組人異常凝血酶原蛋白 |
| 別 名 | Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin; coagulation factor II (thrombin); DCP; Factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain. |
| 理論分子量 | 31.8kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5mg/ml |
| 物 種 | Human |
| 序 列 | 44-413/622 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | HEK293 cell |
| 標(biāo)簽 | C-His |
| 緩 沖 液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or malabsorption) and in those taking warfarin or other medication that inhibits the action of vitamin K. SWISS: P00734 Gene ID: 2147 正常肝細(xì)胞中，在內(nèi)質(zhì)網(wǎng)內(nèi)可將DCP羧化使之成為有活性的凝血酶原，一旦機(jī)體需要，凝血酶原即可轉(zhuǎn)變成凝血酶參與機(jī)體的各項(xiàng)生理功能，當(dāng)有腫瘤細(xì)胞發(fā)生時(shí)，DCP明顯升高。DCP主要用于肝癌方面的研究；有學(xué)者認(rèn)為：聯(lián)合應(yīng)用DCP和AFP對(duì)于早期診斷HCC（原發(fā)性肝細(xì)胞癌）有較大的幫助。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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