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胃蛋白酶原C單克隆抗體

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產(chǎn)品編號V4202
英文名稱PGII
中文名稱胃蛋白酶原C單克隆抗體
別    名PEPC_HUMAN; Gastricsin; EC:3.4.23.3; Pepsinogen C; PEPC; PGC; progastricsin;  
克 隆 號2D6
理論分子量42kDa
細(xì)胞定位分泌型蛋白 
性    狀Lyophilized or Liquid
緩 沖 液PBS (ph=7.4)
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq].

Function:
Hydrolyzes a variety of proteins.

Subcellular Location:
Secreted.

Similarity:
Belongs to the peptidase A1 family.

SWISS:
P20142

Gene ID:
5225

Database links:

Entrez Gene: 5225 Human

Entrez Gene: 24864 Rat

Omim: 169740 Human

SwissProt: P20142 Human

SwissProt: P04073 Rat

Unigene: 1867 Human

Unigene: 9735 Rat



胃蛋白酶原C(PG-C)主要用于胃癌及其癌前病變易感性的關(guān)系。
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