| 產(chǎn)品編號(hào) | bs-42218P |
| 英文名稱 | Recombinant human LPL protein, N-His |
| 中文名稱 | 重組人脂蛋白脂酶 |
| 別 名 | Lipoprotein lipase; LIPD; LIPL_HUMAN; LPL; LPL protein; EC 3.1.1; EC 3.1.1.34; HDLCQ11; LPL; LPL protein; MGC137861. |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | ＞1.0 mg/ml |
| 物 種 | Human |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 標(biāo)簽 | N-His |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 8M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation. SWISS: P06858 Gene ID: 4023 脂蛋白脂酶（lipoprteinlipase，LPL）是甘油三酯降解為甘油和游離脂肪酸 (FFA)反應(yīng)的限速酶,是脂肪細(xì)胞、心肌細(xì)胞、骨骼肌細(xì)胞、乳腺細(xì)胞以及巨噬細(xì)胞等實(shí)質(zhì)細(xì)胞合成和分泌的一種糖蛋白與機(jī)體的脂質(zhì)代謝及肥胖與否密切相關(guān). 近年來(lái)研究認(rèn)為：LPL可通過(guò)粘附作用，促進(jìn)了單核細(xì)胞血管內(nèi)皮細(xì)胞及腫瘤壞死因子（TNF）的分泌、血管平滑肌細(xì)胞增殖等因素，導(dǎo)致動(dòng)脈粥樣硬化的加重。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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