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重組小鼠PD-L1蛋白

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產(chǎn)品編號bs-43632P
英文名稱Recombinant mouse PD-L1 protein, C-hFc (HEK293)
中文名稱重組小鼠PD-L1蛋白
別    名CD274; B7 H; B7 H1; B7 homolog 1; B7-H1; B7H; B7H1; CD 274; CD274 antigen; CD274 molecule; MGC142294; MGC142296; OTTHUMP00000021029; PD L1; PD1L1_MOUSE; PD1L1_MOUSE; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL 1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1; RGD1566211  
理論分子量51.5kDa
性    狀Lyophilized or Liquid
濃    度>1mg/ml
物    種Mouse
序    列19-238/290
純    度>90% as determined by SDS-PAGE
純化方法AC
內(nèi)毒素Not analyzed
表達系統(tǒng)HEK293 cell
標簽C-hFc
緩 沖 液PBS (pH=7.4)
保存條件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

SWISS:
Q9EP73

Gene ID:
60533

程序性死亡配體1(B7-H1)可以促進上皮細胞的惡性轉(zhuǎn)化,保護表皮細胞免于失巢凋亡,在腫瘤的發(fā)生,進展和轉(zhuǎn)歸中發(fā)揮重要作用.
目前對CD274信號通路的進一步的研究必將為自身免疫性疾病、病毒感染性疾病和器官移植后排斥反應中T細胞介導的免疫應答調(diào)控提供了新的途徑.B7-H1在癌癥、類風濕、HIV感染等疾病中發(fā)現(xiàn)B7-H1有負調(diào)節(jié)作用。對B7-H1路徑進行調(diào)控有助于自身免疫病及惡性腫瘤的治療。
產(chǎn)品圖片
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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