| 產(chǎn)品編號(hào) | bs-44018P |
| 英文名稱 | Recombinant human MPO protein |
| 中文名稱 | 重組人髓過(guò)氧化物酶蛋白 |
| 別 名 | Myeloperoxidase; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN. |
| 性 狀 | Liquid |
| 濃 度 | >0.5mg/ml |
| 物 種 | Human |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 2M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] SWISS: P05164 Gene ID: 4353 髓過(guò)氧化物酶MPO,作為一種白細(xì)胞酶,具有介導(dǎo)炎性反應(yīng)、調(diào)節(jié)免疫應(yīng)答等多種功能,并可參與疾病的發(fā)生發(fā)展過(guò)程。同時(shí),髓過(guò)氧化物酶基因存在基因多態(tài)性,也影響機(jī)體對(duì)疾病的易感性. 在正常淋巴組織中和各種髓樣細(xì)胞增生癥中，MPO均有較強(qiáng)表達(dá)，如：淋巴樣細(xì)胞、原核細(xì)胞、肥大細(xì)胞、漿細(xì)胞以及各種上皮源性腫瘤和肉瘤等。 髓過(guò)氧化物酶(myeloperoxidase,MPO),是一種血紅素蛋白，富含于中性粒細(xì)胞中,由粒細(xì)胞進(jìn)入循環(huán)之前在骨髓內(nèi)合成并存儲(chǔ)于噬天青顆粒內(nèi)。外界刺激可導(dǎo)致中性粒細(xì)胞聚集，從而釋放髓過(guò)氧化物酶。MPO的相對(duì)分子量為150kDa，是由兩個(gè)亞單位通過(guò)共價(jià)結(jié)合形成的四聚體，每個(gè)亞單位又有一條重鏈α（相對(duì)分子量60kDa）和一條輕鏈β鏈（相對(duì)分子量為15kDa)構(gòu)成。（重鏈和輕鏈通過(guò)二硫鍵結(jié)合） |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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