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促黃體生成素α-亞基單克隆抗體

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產品編號V6406
英文名稱Human LH
中文名稱促黃體生成素α-亞基單克隆抗體
別    名LSHB_HUMAN; Lutropin subunit beta; Lutropin beta chain; Luteinizing hormone subunit beta (LH-B; LSH-B; LH B; LSH-beta); CGB4; HH23;  
克 隆 號18H11
理論分子量16kDa
細胞定位分泌型蛋白 
性    狀Lyophilized or Liquid
濃    度1mg/ml
緩 沖 液0.01M PBS(pH7.4)
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹Luteinizing Hormone is a member of the glycoprotein hormone family. Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Mutations in the Luteinizing Hormone (LHB) gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.

Function:
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Subunit:
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular Location:
Secreted.

Tissue Specificity:
Pituitary gland.

DISEASE:
Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the glycoprotein hormones subunit beta family.

SWISS:
P01229

Gene ID:
3972

Database links:

Entrez Gene: 3972 Human

Entrez Gene: 16866 Mouse

Entrez Gene: 25329 Rat

SwissProt: P01229 Human

SwissProt: O09108 Mouse

SwissProt: P01230 Rat



LH和FSH都是垂體前葉產生的,由兩條多肽鏈(即а和β亞單位)經非共價鍵結合的糖蛋白。LH和FSH都是呈脈沖式分泌,故有較明顯的日內和日間變異。
女性月經中期的LH高峰促成排卵,男性LH主要刺激Legdig細胞產生睪丸酮,又協(xié)同F(xiàn)SH促進精子成熟。與FSH同時測定,是研究和判斷下丘腦 — 垂體 — 性腺軸功能的常規(guī)檢查方法。LH的測定在預測排卵時間上具有特殊重要意義,它還可用于絕經期檢查,不孕癥診斷和內分泌治療的監(jiān)測等。
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